What kind of terrain are you flying over? Do you have any SE climb performance where you are flying?
From others I have learned, study a VFR chart of where you are going so you have a "lay of the land" for obstacles and terrain. Be careful of high winds aloft on approaches as they can blow you beyond the 10nm circle as Lear Crew made that mistake several years ago in the NE USA and ended up in CFIT. But they only made that mistake once!!!
A retired Eastern Airlines Captain who ended up flight instructing told me he had higher personal minimums for IFR twin flying than SE.
A FAA guy told me that you can't do a a SE ILS in a twin and execute a missed approach, he said you'll spin it in. I never practiced it so I'm not sure if it's entirely true but I believe there's some merit to it as it ties in with Eastern Airlines Captain.
Always leave yourself a way out.