Sounds like my machine. Increased the RAM from 2 to 4GB and has noticably slowed down while working.
Don't know if it's true on your system, but I upped the virtual memory in line with the increase in RAM and it seems to be using it a lot more than it was before. Could that be it? Continually swapping large files back and forward between the RAM and hard drive?
I'm using 3D CAD and it is slower now than when I had the previous version of the software and 1GB RAM. Go figure...