Last few months I have been getting complete lockups requiring reboot with XPSP2/IE6/Logitech Cordless Combo MX Duo, but only in IE. Even C-A-Del is dead. Drivers appear to be up to date.
Things I know:-

I should be using Firefox/Opera etc and/orLinux
Things I will do:-

Revert to old wired k/b+mouse
Uninstall/reinstall Logi Combo
The Combo uses basic system drivers for ordinary functions, only needing Logitech drivers for 'Itouch' function (I don't use)
I bravely installed SP3 yesterday and problem continues. In the interim, has anyone experienced the same?
Update: removed Logitech 'Mouseware' and ran old wired mouse - same. Seems to be mainly in 'Links' column when I try to drag an item.