Dont forget the "keep the little wife happy" program.
Either your wife will love Southern France or she will leave ( you too), so start the exercise by forgetting tax and concentrate on quality of life. If you have any doubts if she is up to it - stay where you can be with her most frequently. If you belong to the 20% minority of pilots who actually married a girl who can put up with our way of life long term - GO,GO,GO and learn French asap. And never whine about her spending too much in LaFayette ( she will) while you do what mortals think is work.
Wx and connections are better in Nice, but TLS and Western France has a lot of charm.
We never looked back after moving there.