Having flown flowers out of Bogota over a hundred times in the Classic I am not surprised to see on crash after take-off like this one.
Everything is balls to the walls and every limit is reached and sometimes exceeded, all of that at high elevation and at night when the crews are dog-tired and should be in bed.
The engine out procedure is confusing at best, and don't work too good as some of the beacons needed to fly the procedure are out of service or too weak to pick up.
Even with 4 engines turning we had a terrain warning during clean-up after a BOG departure.
A company I worked for lost a 747-200 in MDE as the Nr. 1 engine exploded right at V1 and the crew did not get the airplane stopped.
YouTube - Tradewinds Boeing 747 Rejected Takeoff Crash
Turns out Kallitta had overhauled the engines we used on the classics.
Perhaps there is a trend here, Brussels and all...?