My crowd is not quite a major but I did exactly as you propose.
I am a long-hauler by choice but was never going to pass up a jet command opportunity. We don't have slot hassles down here but the multiple sector days and no long blocks off got old. As soon as my "lockon" was served on the 737 I transferred back to longhaul. I have never regretted the move. Left to right seat change did involve a CRM trg module.