As a passenger, do I want to travel point to point, with 250 other bodies, or point to hub to hub to point, with 500 other bodies for the longest bit...
Personally, I think the 787 (or A350) route is the one I would prefer...and I wonder how the economics will stack up. I'll guess that, per passenger, the A380 is cheaper on it's particular leg, but add in the one or two minor flights at each end, and maybe a single 787 hop begins to look more cost effective?