Concur with Old Fella.
Lost a tyre on a tristar. Found out after landing 9 hrs later when we had a truck light and asked ATC to check the gear.
On big jets unless someone sees it happen you may not have any indications until landing. Then truck lights and brake temps will give the game away.
New aircraft are required to have a system to stop the wheels rotating before they enter the bay. This is to prevent flailing rubber from damaging stuff in the bay.