The days of 3 or 5 day layovers are long gone.
Economics.
I guess this trip fits under FAR 121.483, but it does seem a tight fit.
121.481 is out of the question.
http://www.risingup.com/fars/info/part121-483-FAR.shtml
http://www.risingup.com/fars/info/part121-481-FAR.shtml