The Airbus guys at BA seem to be racking up over 800 hours a year which due to the chaos that is LHR means that most people bid off the fleet as soon as they can as it really is exhausting on short haul (so I'm told).
They're wimps. Having done that for my last years in BA I can assure you it is not nearly as exhausting as dragging oneself out of bed around 4am for five days in a row to fly four sectors or getting home at 1 am or later for five days in a row after four sectors. Factor in the travelling time at the beginning and end of each day and you're out of the house for up to 14 hours a day if you have a lengthy commute. No, it's not really exhausting at all compared to EZY. Psychologically wearing, perhaps, because of "the chaos that is LHR" but exhausting it aint. Think of those 5 star hotels in places such as Rome, Paris, Vienna and Prague. I still miss them!