I've flown maybe 25 different CB/CBi airframes and every single one of them was right seat PIC. I've flown 9 different C's and they were all left seat PIC. For this reason all the CB/CBi's I've flown could not carry more than 2 people.
My 6penth worth: I've flown 900hrs in the 300, 70hrs in R22, I'd choose the 300 every time. Main reasons: weight limitations, cockpit size, rotor inertia, 'twitchiness' and cyclic control. R22 is alright if you have a long way to go and/or you own the aircraft...