Much depends on the distance to the airport (both the GA one and the big one) and on the distance one needs to travel to the ultimate destination at the far end.
For the highest business travel value, you would (in most cases) fly your GA plane to the same big airport - because that is where the customer will naturally expect to meet you, and the meeting may even be held there - and take the landing and handling charges on the chin.
But I think this is digressing from the original Q.
The key thing is to structure one's flying so that one gets a regular dose of value out of it. The "value" can be just the fun of being in the air, or it can be going places one cannot easily get to by road, with great views enroute.
I arrange to fly at least once a week, which prevents me getting fed up with it, while maintaining good currency. With some long trips also, this comes to ~150hrs/year which is pretty reasonable.
One also needs to be clear about a good match between one's mission requirement and the plane one has. There is a tendency for owner pilots to move up and up in mission capability and eventually they end up flying something which is very complex, expensive, and with endless issues, and they get sick of it. I've known people who did this and suddenly gave up flying totally, which seemed a shame having come all that way. Similarly at the bottom end: I think a lot of people get into a low end C150-like spamcan and are disappointed that they cannot realistically fly it to southern Spain.