It also helps if your departure airfield is hassle free and convenient. The smaller less sophisticated airfields are often much more convenient time wise - 2 minute walk from ground to air side and as Chilli says you can so much of the preparation in advance and if you are doing a regular run you soon get to know the ropes.
I know which I would rather do, even if the a/c is quite basic. Yes there is the weather factor but that can apply to driving too sometimes!