Amanda, getting past the CV stage probably won't be a problem. The problem might come at interview time, not much you can do to hide a lower leg amputation when you're sitting across the table from someone.
As for it being a problem, well, as long as you can pass a class 1 medical, and prove that you are capable of evacuation safely in the event of an emergency then you stand as good a chance as any of us low hours bods.
Good luck and happy flying!