In panic mode when something like this happens a lot of people start to deal with the problem and forget to check their insurance. Cost of hotel/later flight may be covered, alternatively cost of upgrade. Personal experience here - last year I had to stay in Melbourne 9 extra days due to illness and rebook - insurance covered the lot, but I had to get doctors letters.
If all else fails and she can't blag or buy an upgrade I would try to get a window and aisle seat at the back - the back seats are often emptier than the front (never figured out why, they get there same time) and chances are there would be nobody in the centre seat. This would give a chance for husband to ask for a move, and she could have the row of three to lie down. I'm sure CC would be sympathetic.
Best wishes to her, anyway
UFO