Ive flown from KJAX to KEYW many times, on the multi I just cut thru the everglades straight to EYW (which is a time/fuel saver) but on the single you have to follow the east coast via miami and on to the keys. Since Im further up north I stop in West Palm Beach to Refuel (I always fly on the heavy side/ fuel limited) But most people that solo down there, always stop on marathon refuel then head to keywest. Good Luck