A friend told me he and other members of his crew submitted 4 ASRs on his last IAH flight, all different, but all to do with fatigue and inability to gt any meaningful rest in the hotel.
But I also know the doctors are complaining that so few ASRs are being submitted, they don't have a leg to stand on when they pass on the comments about fatigue from pilots who have come in to see them at the medicsal centre.
On my last IAH, the second captain had been called out - after his good friend had told him 30 minutes earlier over the phone that he was going sick for the flight because he felt too tired to do it. (A few not totally good natured mutterings were heard about what he would say to his friend when he next saw him.)