I wear disposable ones continuously (I sleep with them in). Never had any problems whatsoever even on ultra-longhaul flights (as a pax), including sleeping with them in on the flight.
If your eyes tend to dry out, I recommend you to get high quality contact lens eye drops (moisturising type) that you can use whilst wearing them, or try different types of lenses (optometrist often has samples for you to try).
For flying and driving, I find that contact lenses are much nicer than spectacles (much less risk of dropping them for a start, and no reflections etc.). Another benefit is that no prescription sunglasses are needed as you just pop the normal sunglasses on when necessary.
I was also told by optometrist that contact lenses cause much less eye fatigue that spectables do, as long as they suit you well.
Good luck