My 2 pennies:
Best overall airline is Singapore.
Best airline for 1st class travel is probably Lufthansa, this only applies when using FRA or MUN with their 1st class terminals - simply excellent.
Best short haul carrier for me is a budget operation, Air Berlin. Superior to full cost and other budget airlines.
Most upgrades - Lufthansa. Particularly good when flying out of Frankfurt because they seem to upgrade any LH card holder from C/D to F when the plane is full of American businessmen because they're all UA card holders.