Yes it looks as though the Owl might have given the Mossies a few more worries, especially the 219A-6, dedicated Mossie swatter version.
He 219A-6 was a conversion from the He 219A-2/R1, powered by 2 × Daimler-Benz 603L, rated at 1,750 hp each, and fitted with nitrous-oxide. This version had no Shräge Musik, and no armor, to increase performance. It entered service in August 1944.
It looks as though about 250 Uhu’s were made, with tricycle gear and ejector seats, they could have been 1950s technology. These were classic AI equipped nightfighters with a relatively short ranged radar, needs must then that they operated in close concert with ground controllers and were part of a system that had, compared to the numbers in the bomber stream, a low saturation level.
Hence the deployment and success Wilde Sau - Wiki has this on the subject.
The Wilde Sau force scored their most notable success during the bombing of Peenemunde on August 17, 1943. Mosquito bombers had dropped target marker flares over Berlin and most of the night fighter force was sent there. When it was realized what was really happening, most of these planes were too far away and too slow to intercept the raid. However the much faster Fw 190’s being flown by the Wilde Sau forces were able to easily catch them, and about 30 planes entered the stream and shot down 29 of the 40 bombers lost that raid