Having worked both runway layouts, each has benefits and disadvantages. In the UK, many airfields were built by the miltary with intersecting runways. This reduces the max crosswind component to 30 degrees. The main disadvantage with more than runway one is the cost of lighting and approach systems. To reduce costs, several airfields change the status of a runway which is not often used to a taxiway.
In terms of use from an ATC point of view, you simply use what is available and get on with it.