ME/IR, without question.
CPL - you choose; which would you prefer to do, PFL or single engine work? I can't imagine any employer is going to care which you did your CPL on as it is only a hoop to jump through.
Personally, I was better at single engine work than PFLs, but that's a personal preference. Obviously though, until you have your MECR, you'll not know which you prefer.
Convention is SE CPL & ME IR.