Agree with Frostbite, never had a problem with the reg cleaner in Ccleaner (click on issues; should offer to make a backup) nor TweakNow.
Advanced Windows care, by Iobit seems pretty darned good, too.
Opinion is fairly divided about using reg cleaners at all. I do, but a lot of fairly canny people say best not to.
Think I borked my OS a coupla years ago by overenthusiastic reg cleaning, it definitely can be done.