Hi Meteor FL54,
I have never heard of anything as daft as presurisation cycles. After all, we're only experiencing the equivalent of going from ground level to about 8000ft amsl on every setor which, if you think about it, is a depressurisation. It's only pressurised with respect to the outside environment which, thankfully at OATs of less than -50, we don't experience!
But with respect to which is healthier, I can't answer that. But what I can say is after doing 13 years of what you've been doing and now having spent a year doing four sector days with a low cost carrier, I feel much more relaxed and healthier than before. But then maybe that's because I'm no longer married as well...
Seriously, long haul suits some people, short haul others. It's up to you to decide which is best for you I guess.