Mike Jenvey,
Several computer forums suggest on-going compatibility problems with Lavasoft & Vista.
Including lavasoft's own support forum.
LS Forum Post This despite the fact that the latest LS blog entry on the official site indicated it would be Vista-ready at the end of August.
(Heck, it was supposed to be Vista-ready when they first released it a few months ago!)
I'd use something else. Something better. (Which is almost anything.)