Over water? The A340. It has 4 engines, the others have two. Big difference in my book, don't care what FAA/CAA/'experts' say, about 2 engines being just as safe as 4.
If 4 engines cost the same (in all ways) as two, I guarantee ALL airlines would fly with 4 engines, and all long haul jets would be built with 4.
One day, a large jet with two engines on ETOPS 180/207 or it's current equivalent, will come down mid - pacific with twin engine failure. I don't intend being on that plane.