123.45 is in use by the French. Heard a conversation on this frequency over Northern France last year which was interrupted by an annoyed French controller advising that it was a sector frequency. For use on the Atlantic only it seems.
I've no problem with the use of 121.5 for any genuine help that he/she may require but constant aggressive "YOU'RE ON GUARD" just makes it worse. Also, surely practise PAN's can be rehearsed in the flying school. If you get your RT licence by a practical test indoors I cannot see why a similar simulation cannot be done for these. Fact is that it is a nuisance and often results in 121.5 not being monitored over busy UK airspace in order to merely hear ATC instructions. Just a thought