As somebody in the hiring business explained to me it can come down to age and flying hours. 40 years old and 200 + hours no turbine or heavy transport experience or the alternative 40 years with a type rating, a few thousand hours in transport category aircraft.
From a company point of view the answer is a no brainer, from a wannabee point of view it sucks
There will always be people saying go for it, pilot hiring boom etc, my advice would be if you can afford to lose the money then go ahead, be prepared for a lot of hard work with the possibility of not getting a job at the end of it.