can't be any worse than a 747 depressurised
When you are depressurised then you can keep the pax & crew on oxygen and remain at MEA until clear of the high terrain, whereas when you have an engine out your max altitude is limited by aircraft performance. I haven't flown the Tripler so I was interested in what its single engine performance is at heavy weights relative to the high MEA's on B330/B215 air routes adjacent to the Tibetan plateau (in particular the -300ER which wouldbe the model used on the route).