EGBM,
On that basis, the last real ground-breaker was the 367-80. Everything else since then (including the 747 and A380) has been evolutionary.
All long tubes, swept wings low on the fuse, with engines in pods.
Double-deck aircraft? Old hat. Been done before, sixty years ago.
The Dreamliner (if one is to believe the press) is a leap due to the technology employed in its innards, its engines and in the construction of the airframe (ie. mostly composites).
How that last point will go in 15-20 years when they go to scrap the things will be interesting - how do you melt down carbon fibre?!