For me the collective was very intuitive and required NO getting use to.
What I really liked about the 222 collective mounted throttles-especially for one converting to a twin for the first time-is the throttle layout: The left engine (#1) is on the left side and the right engine throttle (#2) is on the right side (go figure).
I know it sounds rudimentary but I have seen pilots get it mixed up on the 212 where the left engine throttle is on the bottom and the right is on the top (if I remember correctly).
It’s been 15 years since I’ve flown one [222]; it was a good little IFR platform though it really sucked on power, you didn’t vertical out of anywhere!