Well it took us in Big Airways a long time to upgrade- it's the luck of the draw (and the seniority system). 19 years. I seriously doubted my ability to fly with the left hand. It took, about, being conservative, very approximately, without putting too fine a point on it....say in the region of about roughly 3 minutes to get used to it, and know I didn't ever want to go back!
The biggest problem is when the cabin crew or groundstaff come up with a question for the Captain, and you just sit there vacantly looking out of the window waiting for 'the Boss' to answer......'cept it's you now! Know your regulations. As for the fancy flying on the other side- no problemo at all.