Shoey, if it is fatigue that you are looking at as a causal factor, did you read the final report on the accident of N90AG at Birmingham on Jan 4th 2002. Whilst not directly fatigue related, the whole issue of time zones, medicinal sleep aids and other factors led to a poor decision.
On another note, how do middle east based crews where hubs (i.e DXB) come alive with flights departing around 02:30 cope on a regular basis? As someone else has said, assuming a good quality sleep pattern prior to getting up to fly at those times is virtually impossible!