There have been several cases of crew incapacitation with fatal results due to mishandling of the pressurization systems. One was a bizjet (can't confirm the type) departing Europe and terminated in the North Atlantic. Another was a Learjet with a professional golfer onboard (USA operation) and another was a BE200 in Australia. In the last 2 cases the wreckage was available and the bleed switches were found in the off position. I and thousands of other pilots have operated these aircraft types without incident over hundreds of thousands of hours.
I say again: Airmanship 101