As a general rule, if I'm on a local flight (eg. a triangular route and turning at Point A and Point B, returning to the same airfield) I'll fly at an odd altitude, say 2700ft, rather than the oft-used 2000ft or 2500ft.
If I'm travelling cross-country and cloud base permits, I'll usually aim for a quadrantal flight level, providing my course isn't taking me just either side of 180 etc etc (which would mean a level change at every waypoint!). If the course is a dead straight line then this isn't a problem.
All of my flying is VFR.