Hey there, i cant see any issues with doing at all, as long as you have the right hardware support.
My graphics card allows three outputs, and you can select what you want the other screen to be, ie extended displays, show another unique screen, be a clone of the origional screen and so on.
I know on FS you can use the screen extend and because you can create new windows you can show different things on each monitor.
I dont have the game in question, but it works with a screen extend on TOCA three.
I know you can get a nice little adapter now that splits one output to three screens, its $99 i think and flightsim.com store sells it.