I guess therein lies the beauty of the An-124. Brilliant freight uplift and it can tote about 80 fully packed troops upstairs.
I imagine it would have the same limitations, perhaps on a grander scale, to those that Orac pointed out.
But, TD, you're right about the mixed fleet. We often knocked AN & recently QF about fleet variety & how some airlines do so much better operating a single type (with qualifications of course). Perhaps if some smart operator developed a true multi role support aircraft, they'd make a fortune?
Would overwing engines on the C-17 mitigate the jet wash to acceptable limits? Just a thought....