From a practical point of view ..
(a) don't go outside the certification envelope limits. This puts a significant load on the system designer and the users to make sure that the system is both workable and valid.
(b) don't calculate too much of a misload so that the stab setting is too far wide of the mark. A small mis-trim is not going to be a problem .. but a major mis-trim might well be a show stopper ... try a max aft CG takeoff in the sim with the stab set for a max forward load .. guaranteed to get everyone's undivided attention if the pony rears its head at (VR - a lot of knots).
Main thing is for the pilot to use the loading system in the manner intended by the designer and (hoperfully) published in operational documents ..