My situation is a little different than some... I am *very* lefty (having spent a small fortune on left-handed guitars over the last 30 years to prove it!)... I flew PC-based combat simulators (e.g. Falcon 3, Falcon 4, Longbow, Flight Simulator, etc.) for years before going at it for real, and the PC control setup that I had was very righty-oriented (stick in right hand, throttle/collective in left - due to those (CH Products) control shapes, you *have* to fly them righty-tighty) so by the time I started real world flight training it was a no-brainer.
Dave B.