I agree NIMFLT. The crew were complacent, but so was the controller. It is just as big a mistake as lining up on the wrong runway as it is to clear an aircraft for TO without looking out of the window. That really shows a lack of staffing that the FAA needs to evaluate. Hard to believe that with all the taxes on aviation, that some of that money can't find its way to properly staffing ATC. I'll trade 1000 TSA agents for 1 Air traffic controller anytime of day.
One idea, I saw a picture of some airports in Scandinavia and noticed that the runways were painted yellow. I can only assume that this is done due to the amounts of snow that they get, but it made me think. I wonder if painting runways in a unique color would help the situation. One thing for sure, airport markings need to be overhauled and simplified enough so that even a caveman could navigate them. They need to be more intuitive and some airports need to simplify their layouts.