I fly classics. Just got out of the sim. Our sim is ex-KLM and has 'R' powered Pratts on it; thats 54,000 lbs. of thrust each. During a max weight takeoff;833,000 lbs, full rudder trim is required + a bit of aileron to keep it straight.
I have not tried it on two engines/one side, but my firm belief is it would not be controllable. We do a two engine approach and landing scenario at max landing weight 630,000 lbs. and it is quite controllable. VMCG on an 'R' powered plane is 131 knots. V2 is 188 knots and it takes all 11,000 feet to get it off the ground on 3 engines with one quitting at V1. V1 was 157 knots.
A few years ago, our company lost 2 engines on a DC-8-61 coming out of France somewhere, and it was not pretty. However, there were two very experienced flight engineers on board and a rather crafty captain, and they survived.