For most 3/4 engined beasties, the 2EI scenario addresses cruise only .. ergo, during takeoff, with a second failure, one is going to be very interested in
(a) gross weight .. dumping would be the norm
(b) configuration and speed ... usual to require a descent during which the aircraft is part/wholly cleaned up and a speed more useful than V2 achieved.
Definitely no guarantees in this situation ...
The 747 specialists will, no doubt, talk in respect of that machine ....