I've been there a few times IFR but they do accept VFR traffic; they have a separate GA terminal (called the "old terminal") which is very nice, very friendly and quite empty. Landing+parking around £40 for a couple of days.
Going to Prague VFR from the UK is not that easy because there is some terrain in the way and it's not easy to be sure that the cloudbase will be well above it for the whole distance. Funnily enough whenever I went there under IFR it would have been flyable VFR but when (some time earlier) I planned to go there VFR (below the cloud) I had to scrap it every time due to cloudbases...