We did it as a group this year. It is very easy and accomodating if you are competant on the radio on are capable of accurate navigation. The VFR joins are by VRP's from North, South, East and West. It is a very busy international airport. You must have your aircraft docs ready for inspection as they will give them a real going over.
Another good route in as well is to fly into Korlovy Vary and then from there into Letnany which is actually close to Prauge that than the main airport it also has a fascinating military airport next door with an amazing museum stuffed with Mig's and other cold war hardware! We visited most of the airfields around there. The Letnany guys are a gliding club and they were fantastic and with Avgas half the price of the main airport worth the visit!