Yes, absolutely! The 4162 update went well with my Pentium/Win2K PCs and VirusScan 4.0.3a but the Celeron/WinME/VirusScan 5.0.5 system did just as you describe. I got an MSSCAN32 error that required 4 "Rtn"s to get Win to load. In was then so bad that I couldn't uninstall VirusScan using the normal methods.
I got rid of VirusScan by removing as many of the files as I could by brute force then reinstalling it. Then I was able to uninstall it and install the latest version (5.21) followd by the 4162 Update and all was well.
Took some sorting out but all well now.