I persoanly can't see it happen in most cases, and I persoanly wouldn't want to fly on a plane with no flight crew.
However, I COULD see a non-pilot (or certainly a 1 pilot) plane doing domestic flights (lets take the UK as an example)
I could see something like an A319 or A320 doing say LHR-MAN or LHR-NCL, since they don't go over any oceans or seas (so are over land at most times), they don't cruise at above 30,000ft, probably don't go at maximum crusing speed (although I could be wrong), don't go into a different countries airspace, the flights are relativly short and don't carry a huge number of passengers or cargo.
And so the airlines could perhaps push something like that, however, once you get into long-haul routes and flying over vast oceans and seas, it's a completely different story.
wrightbrothers