At times its like trying to read Arabic. You have to fit the acronym into the context of the sentence. The classic example is ILS which is either Instrument Landing System or Integrated Logistic Support.
I got a letter from the head shed asking me to do something about some nonsense acronym. I phoned him to ask what it meant and he told me he didn't know. He was just passing the message on from a letter he received. I said if he ever found out what it meant, he should get back to me. Never heard from him again!
Not an acronym, but I've drafted 2 letters that have been signed off by very high priced help with the phrase "onageristic estimate" in them.
"The name onager comes from the Greek onagros or wild ass" hence Onageristic Estimate = Wild Ass Guess