Nope. Not a chance in hell of getting directly into a Major airline in the states on an H-1B visa as an H-1B is not a Green Card. H-1B visas are for foreign professionals in computers, medicine, academic research, law, engineering and nursing. Piloting Aircraft is not recognized by the US Government as a profession in dire need of foreign workers ,AND IT NEVER WILL BE, so foreign pilots will not be granted H-1B visas.
With the economy going south - especially the dot.com sector - in the States and a Republican President at the helm you can be assured of a serious reduction in the numbers of H-1B visas issued to foreigners.
If you want more info go to the American Embassy in Malaysia or read up on visas on the INS website.