Like with any other flight... just be well prepared. Before you depart for your trip... review your area and approach charts, NOTAMS, AIM, Airport Facilitiy Directory, and any other publications you use in the course of your operations.
There are detailed STARS into KSEA depending on the direction of your arrival. If you arrive at off peak hours you are usually radar vectored for the final approach... to both north and south approaches. They also have Charted Visual Approache Procedures which are often used too. The Air Traffic Controllers have a tendancy to speak rather fast and may not always follow the ICAO phraseology format... so be prepared. If you are in doubt just ask them to repeat their instructions.
Taxiways are well marked.
Once in Seattle... sample some of the sea food and martinis... unlike any other place you have been.
Have a great trip and don't forget the tour at Boeing.