I often fly Plymouth to Humberside to visit the rellies (5.5 hrs each way in the car becomes a more tolerable 1.4 hrs in the air).
Brm and E.Mids are usually very accomodating.
East Mids may ask you to route E of the motorway or Shepshed-Long Eaton so be aware of VRPs.
Sounding slick on the radio may also ease your transit.
SB